This core provides our experience with tape-capture of intact frozen sections of mineralized tissues followed by whole section imaging of the fluorescent and chromogenic signals emanating from the section. It has proven useful in imaging the accumulated mineral, fluorescent mineralization lines, AP and TRAP positive cells, and GFP, EdU and immunofluorescent signals all from the same section. This multimodal histological approach provides discriminating biological signals for interpreting injury/repair and transplantation models of skeletal tissues (long bone, calvaria, knee, TMJ and teeth) and computer-controlled high throughput trabecular static, dynamic and cellular histomorphometry that is particularly attractive for analyzing IMPC-produced KO mouse lines. These techniques can be contracted through the core and we offer hands-on training to laboratories that what to implement these methods.